Four base recognition by triplex-forming oligonucleotides at physiological pH

We have achieved recognition of all 4 bp by triple helix formation at physiological pH, using triplex-forming oligonucleotides that contain four different synthetic nucleotides. BAU [2′-aminoethoxy-5-(3-aminoprop-1-ynyl)uridine] recognizes AT base pairs with high affinity, (Me)P (3-methyl-2 aminopyr...

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Detalhes bibliográficos
Main Authors: Rusling, David A., Powers, Vicki E. C., Ranasinghe, Rohan T., Wang, Yang, Osborne, Sadie D., Brown, Tom, Fox, Keith R.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2005
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1137030/
https://ncbi.nlm.nih.gov/pubmed/15911633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gki625
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