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Protein knotting through concatenation significantly reduces folding stability
Concatenation by covalent linkage of two protomers of an intertwined all-helical HP0242 homodimer from Helicobacter pylori results in the first example of an engineered knotted protein. While concatenation does not affect the native structure according to X-ray crystallography, the folding kinetics...
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| Izdano u: | Sci Rep |
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| Glavni autor: | |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Publishing Group
2016
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5159899/ https://ncbi.nlm.nih.gov/pubmed/27982106 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep39357 |
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