Altered stoichiometry Escherichia coli Cascade complexes with shortened CRISPR RNA spacers are capable of interference and primed adaptation

The Escherichia coli type I-E CRISPR-Cas system Cascade effector is a multisubunit complex that binds CRISPR RNA (crRNA). Through its 32-nucleotide spacer sequence, Cascade-bound crRNA recognizes protospacers in foreign DNA, causing its destruction during CRISPR interference or acquisition of additi...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Kuznedelov, Konstantin, Mekler, Vladimir, Lemak, Sofia, Tokmina-Lukaszewska, Monika, Datsenko, Kirill A., Jain, Ishita, Savitskaya, Ekaterina, Mallon, John, Shmakov, Sergey, Bothner, Brian, Bailey, Scott, Yakunin, Alexander F., Severinov, Konstantin, Semenova, Ekaterina
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Nucleic Acid Enzymes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5159557/
https://ncbi.nlm.nih.gov/pubmed/27738137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw914
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