S-Geranyl-2-thiouridine wobble nucleosides of bacterial tRNAs; chemical and enzymatic synthesis of S-geranylated-RNAs and their physicochemical characterization

Recently, highly lipophilic S-geranylated derivatives of 5-methylaminomethyl-2-thiouridine (mnm5geS2U) and 5-carboxymethylaminomethyl-2-thiouridine (cmnm5geS2U) were found at the first (wobble) anticodon position in bacterial tRNAs specific for Lys, Glu and Gln. The function and cellular biogenesis...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Sierant, Malgorzata, Leszczynska, Grazyna, Sadowska, Klaudia, Dziergowska, Agnieszka, Rozanski, Michal, Sochacka, Elzbieta, Nawrot, Barbara
Format: Artigo
Language:Inglês
Published: Oxford University Press 2016
Subjects:
RNA
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5159532/
https://ncbi.nlm.nih.gov/pubmed/27566149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw727
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