C5-Substituted 2-Selenouridines Ensure Efficient Base Pairing with Guanosine; Consequences for Reading the NNG-3′ Synonymous mRNA Codons

5-Substituted 2-selenouridines (R5Se2U) are post-transcriptional modifications present in the first anticodon position of transfer RNA. Their functional role in the regulation of gene expression is elusive. Here, we present efficient syntheses of 5-methylaminomethyl-2-selenouridine (1, mnm5Se2U), 5-...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Leszczynska, Grazyna, Cypryk, Marek, Gostynski, Bartlomiej, Sadowska, Klaudia, Herman, Paulina, Bujacz, Grzegorz, Lodyga-Chruscinska, Elzbieta, Sochacka, Elzbieta, Nawrot, Barbara
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7216251/
https://ncbi.nlm.nih.gov/pubmed/32326096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21082882
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