Epigallocatechin Gallate Remodels Overexpressed Functional Amyloids in Pseudomonas aeruginosa and Increases Biofilm Susceptibility to Antibiotic Treatment

Epigallocatechin-3-gallate (EGCG) is the major polyphenol in green tea. It has antimicrobial properties and disrupts the ordered structure of amyloid fibrils involved in human disease. The antimicrobial effect of EGCG against the opportunistic pathogen Pseudomonas aeruginosa has been shown to involv...

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Vydáno v:J Biol Chem
Hlavní autoři: Stenvang, Marcel, Dueholm, Morten S., Vad, Brian S., Seviour, Thomas, Zeng, Guanghong, Geifman-Shochat, Susana, Søndergaard, Mads T., Christiansen, Gunna, Meyer, Rikke Louise, Kjelleberg, Staffan, Nielsen, Per Halkjær, Otzen, Daniel E.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2016
Témata:
Protein Structure and Folding
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5159513/
https://ncbi.nlm.nih.gov/pubmed/27784787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.739953
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