BMI-1 targeting interferes with patient-derived tumor-initiating cell survival and tumor growth in prostate cancer

PURPOSE: Current prostate cancer (PCa) management calls for identifying novel and more effective therapies. Self-renewing tumor-initiating cells (TICs) hold intrinsic therapy-resistance and account for tumor relapse and progression. As BMI-1 regulates stem cell self-renewal, impairing BMI-1 function...

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Foilsithe in:Clin Cancer Res
Main Authors: Bansal, Nitu, Bartucci, Monica, Yusuff, Shamila, Davis, Stephani, Flaherty, Kathleen, Huselid, Eric, Patrizii, Michele, Jones, Daniel, Cao, Liangxian, Sydorenko, Nadiya, Moon, Young-Choon, Zhong, Hua, Medina, Daniel J., Kerrigan, John, Stein, Mark N., Kim, Isaac Y., Davis, Thomas W., DiPaola, Robert S., Bertino, Joseph R., Sabaawy, Hatem E.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2016
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5159329/
https://ncbi.nlm.nih.gov/pubmed/27307599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-3107
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