Synthesis and Characterization of Novel BMI1 Inhibitors Targeting Cellular Self-Renewal in Hepatocellular Carcinoma

BACKGROUND: Hepatocellular carcinoma (HCC) represents one of the most lethal cancers worldwide due to therapy resistance and disease recurrence. Tumor relapse following treatment could be driven by the persistence of liver cancer stem-like cells (CSCs). The protein BMI1 is a member of the polycomb e...

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Argitaratua izan da:Target Oncol
Egile Nagusiak: Bartucci, Monica, Hussein, Mohamed S., Huselid, Eric, Flaherty, Kathleen, Patrizii, Michele, Laddha, Saurabh V., Kui, Cindy, Bigos, Rachel A., Gilleran, John A., El Ansary, Mervat M. S., Awad, Mona A. M., Kimball, S. David, Augeri, David J., Sabaawy, Hatem E.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2017
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7068645/
https://ncbi.nlm.nih.gov/pubmed/28589491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11523-017-0501-x
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