Central Ceramide-Induced Hypothalamic Lipotoxicity and ER Stress Regulate Energy Balance

Hypothalamic endoplasmic reticulum (ER) stress is a key mechanism leading to obesity. Here, we demonstrate that ceramides induce lipotoxicity and hypothalamic ER stress, leading to sympathetic inhibition, reduced brown adipose tissue (BAT) thermogenesis, and weight gain. Genetic overexpression of th...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Contreras, Cristina, González-García, Ismael, Martínez-Sánchez, Noelia, Seoane-Collazo, Patricia, Jacas, Jordi, Morgan, Donald A., Serra, Dolors, Gallego, Rosalía, Gonzalez, Francisco, Casals, Núria, Nogueiras, Rubén, Rahmouni, Kamal, Diéguez, Carlos, López, Miguel
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5157160/
https://ncbi.nlm.nih.gov/pubmed/25284795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.08.057
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