Central Ceramide-Induced Hypothalamic Lipotoxicity and ER Stress Regulate Energy Balance

Hypothalamic endoplasmic reticulum (ER) stress is a key mechanism leading to obesity. Here, we demonstrate that ceramides induce lipotoxicity and hypothalamic ER stress, leading to sympathetic inhibition, reduced brown adipose tissue (BAT) thermogenesis, and weight gain. Genetic overexpression of th...

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Publicat a:Cell Rep
Autors principals: Contreras, Cristina, González-García, Ismael, Martínez-Sánchez, Noelia, Seoane-Collazo, Patricia, Jacas, Jordi, Morgan, Donald A., Serra, Dolors, Gallego, Rosalía, Gonzalez, Francisco, Casals, Núria, Nogueiras, Rubén, Rahmouni, Kamal, Diéguez, Carlos, López, Miguel
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5157160/
https://ncbi.nlm.nih.gov/pubmed/25284795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.08.057
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