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Effects of protonation on the hydrolysis of triphosphate in vacuum and the implications for catalysis by nucleotide hydrolyzing enzymes

BACKGROUND: Nucleoside triphosphate (NTP) hydrolysis is a key reaction in biology. It involves breaking two very stable bonds (one P–O bond and one O–H bond of water), in either a concurrent or a sequential way. Here, we systematically examine how protonation of the triphosphate affects the mechanis...

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Veröffentlicht in:BMC Biochem
Hauptverfasser: Kiani, Farooq Ahmad, Fischer, Stefan
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2016
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5157097/
https://ncbi.nlm.nih.gov/pubmed/27974044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12858-016-0068-7
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