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The Allostery Landscape: Quantifying Thermodynamic Couplings in Biomolecular Systems

[Image: see text] Allostery plays a fundamental role in most biological processes. However, little theory is available to describe it outside of two-state models. Here we use a statistical mechanical approach to show that the allosteric coupling between two collective variables is not a single numbe...

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Bibliografski detalji
Izdano u:J Chem Theory Comput
Glavni autori: Cuendet, Michel A., Weinstein, Harel, LeVine, Michael V.
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2016
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5156960/
https://ncbi.nlm.nih.gov/pubmed/27766843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jctc.6b00841
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