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The double-domain cytidine deaminase APOBEC3G is a cellular site-specific RNA editing enzyme

APOBEC3G is a cytidine deaminase with two homologous domains and restricts retroelements and HIV-1. APOBEC3G deaminates single-stranded DNAs via its C-terminal domain, whereas the N-terminal domain is considered non-catalytic. Although APOBEC3G is known to bind RNAs, APOBEC3G-mediated RNA editing ha...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Sharma, Shraddha, Patnaik, Santosh K., Taggart, Robert T., Baysal, Bora E.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5156925/
https://ncbi.nlm.nih.gov/pubmed/27974822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep39100
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