Human cellular CYBA UTR sequences increase mRNA translation without affecting the half-life of recombinant RNA transcripts

Modified nucleotide chemistries that increase the half-life (T(1/2)) of transfected recombinant mRNA and the use of non-native 5′- and 3′-untranslated region (UTR) sequences that enhance protein translation are advancing the prospects of transcript therapy. To this end, a set of UTR sequences that a...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Ferizi, Mehrije, Aneja, Manish K., Balmayor, Elizabeth R., Badieyan, Zohreh Sadat, Mykhaylyk, Olga, Rudolph, Carsten, Plank, Christian
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5156912/
https://ncbi.nlm.nih.gov/pubmed/27974853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep39149
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