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Dissecting Torsin/cofactor function at the nuclear envelope: a genetic study

The human genome encodes four Torsin ATPases, the functions of which are poorly understood. In this study, we use CRISPR/Cas9 engineering to delete all four Torsin ATPases individually and in combination. Using nuclear envelope (NE) blebbing as a phenotypic measure, we establish a direct correlation...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Mol Biol Cell
Prif Awduron: Laudermilch, Ethan, Tsai, Pei-Ling, Graham, Morven, Turner, Elizabeth, Zhao, Chenguang, Schlieker, Christian
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The American Society for Cell Biology 2016
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5156537/
https://ncbi.nlm.nih.gov/pubmed/27798237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E16-07-0511
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