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Talin-driven inside-out activation mechanism of platelet αIIbβ3 integrin probed by multimicrosecond, all-atom molecular dynamics simulations

Platelet aggregation is the consequence of the binding of extracellular bivalent ligands such as fibrinogen and von Willebrand factor to the high affinity, active state of integrin αIIbβ3. This state is achieved through a so-called “inside-out” mechanism characterized by the membrane-assisted format...

詳細記述

保存先:
書誌詳細
出版年:Proteins
主要な著者: Provasi, Davide, Negri, Ana, Coller, Barry S., Filizola, Marta
フォーマット: Artigo
言語:Inglês
出版事項: 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5156318/
https://ncbi.nlm.nih.gov/pubmed/24677266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.24540
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