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Talin-driven inside-out activation mechanism of platelet αIIbβ3 integrin probed by multimicrosecond, all-atom molecular dynamics simulations
Platelet aggregation is the consequence of the binding of extracellular bivalent ligands such as fibrinogen and von Willebrand factor to the high affinity, active state of integrin αIIbβ3. This state is achieved through a so-called “inside-out” mechanism characterized by the membrane-assisted format...
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| Pubblicato in: | Proteins |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2014
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5156318/ https://ncbi.nlm.nih.gov/pubmed/24677266 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.24540 |
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