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Targeted Molecular Dynamics Reveals Overall Common Conformational Changes Upon Hybrid Domain Swing-Out in β3 Integrins
The β3 integrin family members αIIbβ3 and αVβ3 signal bidirectionally through long-range allosteric changes, including a transition from a bent unliganded-closed low-affinity state to an extended liganded-open high-affinity state. To obtain an atomic-level description of this transition in an explic...
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Main Authors: | , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2009
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2761229/ https://ncbi.nlm.nih.gov/pubmed/19455709 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.22463 |
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