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Targeted Molecular Dynamics Reveals Overall Common Conformational Changes Upon Hybrid Domain Swing-Out in β3 Integrins

The β3 integrin family members αIIbβ3 and αVβ3 signal bidirectionally through long-range allosteric changes, including a transition from a bent unliganded-closed low-affinity state to an extended liganded-open high-affinity state. To obtain an atomic-level description of this transition in an explic...

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Detalhes bibliográficos
Main Authors: Provasi, Davide, Murcia, Marta, Coller, Barry S., Filizola, Marta
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2761229/
https://ncbi.nlm.nih.gov/pubmed/19455709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.22463
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