Genetic determinants of cytochrome P450 2A6 activity and biomarkers of tobacco smoke exposure in relation to risk of lung cancer development in the Shanghai Cohort Study

Cytochrome P450 2A6 (CYP2A6) catalyzes nicotine metabolism and contributes to the metabolism of the tobacco-specific lung carcinogen, NNK. Genetic variation in CYP2A6 may affect smoking behavior and contribute to lung cancer risk. A nested case-control study of 325 lung cancer cases and 356 controls...

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Bibliographic Details
Published in:Int J Cancer
Main Authors: Yuan, Jian-Min, Nelson, Heather H., Butler, Lesley M., Carmella, Steven G., Wang, Renwei, Kuriger-Laber, Jacquelyn K., Adams-Haduch, Jennifer, Hecht, Stephen S., Gao, Yu-Tang, Murphy, Sharon E.
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5155585/
https://ncbi.nlm.nih.gov/pubmed/26662855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.29963
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