Evaluation of recombinant monoclonal antibody SVmab1 binding to Na (V)1.7 target sequences and block of human Na (V)1.7 currents

Identification of small and large molecule pain therapeutics that target the genetically validated voltage-gated sodium channel Na (V)1.7 is a challenging endeavor under vigorous pursuit. The monoclonal antibody SVmab1 was recently published to bind the Na (V)1.7 DII voltage sensor domain and block...

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Detalhes bibliográficos
Publicado no:F1000Res
Main Authors: Liu, Dong, Tseng, Mandy, Epstein, Linda F., Green, Lydia, Chan, Brian, Soriano, Brian, Lim, Desiree, Pan, Oscar, Murawsky, Christopher M., King, Chadwick T., Moyer, Bryan D.
Formato: Artigo
Idioma:Inglês
Publicado em: F1000Research 2016
Assuntos:
Antibody Validation Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5155501/
https://ncbi.nlm.nih.gov/pubmed/27990272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12688/f1000research.9918.1
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