The cell-autonomous mechanisms underlying the activity of metformin as an anticancer drug

The biguanide drug metformin profoundly affects cell metabolism, causing an impairment of the cell energy balance and triggering a plethora of pleiotropic effects that vary depending on the cellular or environmental context. Interestingly, a decade ago, it was observed that metformin-treated diabeti...

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Bibliographic Details
Published in:Br J Cancer
Main Authors: Sacco, Francesca, Calderone, Alberto, Castagnoli, Luisa, Cesareni, Gianni
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5155371/
https://ncbi.nlm.nih.gov/pubmed/27875520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2016.385
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