Mycolactone subverts immunity by selectively blocking the Sec61 translocon

Mycolactone, an immunosuppressive macrolide released by the human pathogen Mycobacterium ulcerans, was previously shown to impair Sec61-dependent protein translocation, but the underlying molecular mechanism was not identified. In this study, we show that mycolactone directly targets the α subunit o...

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Pubblicato in:J Exp Med
Autori principali: Baron, Ludivine, Paatero, Anja Onerva, Morel, Jean-David, Impens, Francis, Guenin-Macé, Laure, Saint-Auret, Sarah, Blanchard, Nicolas, Dillmann, Rabea, Niang, Fatoumata, Pellegrini, Sandra, Taunton, Jack, Paavilainen, Ville O., Demangel, Caroline
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2016
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5154940/
https://ncbi.nlm.nih.gov/pubmed/27821549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20160662
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