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Mycolactone subverts immunity by selectively blocking the Sec61 translocon
Mycolactone, an immunosuppressive macrolide released by the human pathogen Mycobacterium ulcerans, was previously shown to impair Sec61-dependent protein translocation, but the underlying molecular mechanism was not identified. In this study, we show that mycolactone directly targets the α subunit o...
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| 出版年: | J Exp Med |
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| 主要な著者: | , , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
The Rockefeller University Press
2016
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5154940/ https://ncbi.nlm.nih.gov/pubmed/27821549 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20160662 |
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