Mycolactone subverts immunity by selectively blocking the Sec61 translocon

Mycolactone, an immunosuppressive macrolide released by the human pathogen Mycobacterium ulcerans, was previously shown to impair Sec61-dependent protein translocation, but the underlying molecular mechanism was not identified. In this study, we show that mycolactone directly targets the α subunit o...

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書目詳細資料
發表在:J Exp Med
Main Authors: Baron, Ludivine, Paatero, Anja Onerva, Morel, Jean-David, Impens, Francis, Guenin-Macé, Laure, Saint-Auret, Sarah, Blanchard, Nicolas, Dillmann, Rabea, Niang, Fatoumata, Pellegrini, Sandra, Taunton, Jack, Paavilainen, Ville O., Demangel, Caroline
格式: Artigo
語言:Inglês
出版: The Rockefeller University Press 2016
主題:
Research Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5154940/
https://ncbi.nlm.nih.gov/pubmed/27821549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20160662
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