Protein phosphatase 5 mediates corticosteroid insensitivity in airway smooth muscle in patients with severe asthma

BACKGROUND: The mechanisms driving glucocorticoids (GC) insensitivity in patients with severe asthma are still unknown. Recent evidence suggests the existence of GC insensitive pathways in airway smooth muscle (ASM) caused by a defect in GC receptor (GRα) function. We examined whether other mechanis...

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Publicado en:Allergy
Main Authors: Chachi, Latifa, Abbassian, Mahnaz, Gavrila, Adelina, Alzahrani, Abdulrahman, Tliba, Omar, Bradding, Peter, Wardlaw, Andrew J., Brightling, Christopher, Amrani, Yassine
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5154839/
https://ncbi.nlm.nih.gov/pubmed/27501780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/all.13003
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