Withaferin A induces Nrf2-dependent protection against liver injury: role of Keap1-independent mechanisms

Small molecules of plant origin offer presumptively safe opportunities to prevent carcinogenesis, mutagenesis and other forms of toxicity in humans. However, the mechanisms of action of such plant-based agents remain largely unknown. In recent years the stress responsive transcription factor Nrf2 ha...

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Bibliografske podrobnosti
izdano v:Free Radic Biol Med
Main Authors: Palliyaguru, Dushani L., Chartoumpekis, Dionysios V., Wakabayashi, Nobunao, Skoko, John J., Yagishita, Yoko, Singh, Shivendra V., Kensler, Thomas W.
Format: Artigo
Jezik:Inglês
Izdano: 2016
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5154810/
https://ncbi.nlm.nih.gov/pubmed/27717869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2016.10.003
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