Notch-Nrf2 Axis: Regulation of Nrf2 Gene Expression and Cytoprotection by Notch Signaling

The Notch signaling pathway enables regulation and control of development, differentiation, and homeostasis through cell-cell communication. Our investigation shows that Notch signaling directly activates the Nrf2 stress adaptive response pathway through recruitment of the Notch intracellular domain...

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Main Authors: Wakabayashi, Nobunao, Skoko, John J., Chartoumpekis, Dionysios V., Kimura, Shoko, Slocum, Stephen L., Noda, Kentaro, Palliyaguru, Dushani L., Fujimuro, Masahiro, Boley, Patricia A., Tanaka, Yugo, Shigemura, Norihisa, Biswal, Shyam, Yamamoto, Masayuki, Kensler, Thomas W.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2014
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3911489/
https://ncbi.nlm.nih.gov/pubmed/24298019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01408-13
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