Loss of Nrf2 in Mice Evokes a Congenital Intrahepatic Shunt That Alters Hepatic Oxygen and Protein Expression Gradients and Toxicity

The transcription factor Nrf2 (Nfe2l2 nuclear factor, erythroid 2-like 2) regulates gene expression directly, controlling pharmacological and toxicological responses. These processes may also be influenced by the structure of the hepatic vasculature, which distributes blood flow through compartmenta...

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Bibliographic Details
Published in:Toxicol Sci
Main Authors: Skoko, John J., Wakabayashi, Nobunao, Noda, Kentaro, Kimura, Shoko, Tobita, Kimimasa, Shigemura, Norihisa, Tsujita, Tadayuki, Yamamoto, Masayuki, Kensler, Thomas W.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2014
Subjects:
Nrf2 AND CONGENITAL HEPATIC DEFECT
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4271119/
https://ncbi.nlm.nih.gov/pubmed/24924401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfu109
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