Genomics and CSF analyses implicate thyroid hormone in hippocampal sclerosis of aging

We report evidence of a novel pathogenetic mechanism in which thyroid hormone dysregulation contributes to dementia in elderly persons. Two single nucleotide polymorphisms (SNPs) on chromosome 12p12 were the initial foci of our study: rs704180 and rs73069071. These SNPs were identified by separate r...

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Bibliographic Details
Published in:Acta Neuropathol
Main Authors: Nelson, Peter T., Katsumata, Yuriko, Nho, Kwangsik, Artiushin, Sergey C., Jicha, Gregory A., Wang, Wang-Xia, Abner, Erin L., Saykin, Andrew J., Kukull, Walter A., Fardo, David W.
Format: Artigo
Language:Inglês
Published: 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5154615/
https://ncbi.nlm.nih.gov/pubmed/27815632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-016-1641-2
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