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The Effects of Ca(2+) Concentration and E200K Mutation on the Aggregation Propensity of PrP(C): A Computational Study
The propensity of cellular prion protein to aggregation is reputed essential for the initiation of the amyloid cascade that ultimately lead to the accumulation of neurotoxic aggregates. In this paper, we extended and applied an already reported computational workflow [Proteins 2015; 83: 1751–1765] t...
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| Publicado no: | PLoS One |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5154561/ https://ncbi.nlm.nih.gov/pubmed/27959938 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0168039 |
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