Tumor Regression and Delayed Onset Toxicity Following B7-H4 CAR T Cell Therapy

B7-H4 protein is frequently overexpressed in ovarian cancer. Here, we engineered T cells with novel B7-H4-specific chimeric antigen receptors (CARs) that recognized both human and murine B7-H4 to test the hypothesis that B7-H4 CAR T cell therapy can be applied safely in preclinical models. B7-H4 CAR...

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Enregistré dans:
Détails bibliographiques
Publié dans:Mol Ther
Auteurs principaux: Smith, Jenessa B, Lanitis, Evripidis, Dangaj, Denarda, Buza, Elizabeth, Poussin, Mathilde, Stashwick, Caitlin, Scholler, Nathalie, Powell, Daniel J
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2016
Sujets:
Original Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5154474/
https://ncbi.nlm.nih.gov/pubmed/27439899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2016.149
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