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B7-H4 as a potential target for immunotherapy for gynecologic cancers: A closer look
B7-H4 is a transmembrane protein that binds an unknown receptor on activated T cells resulting in inhibition of T-cell effector function via cell cycle arrest, decreased proliferation, and reduced IL-2 production. B7-H4 is up-regulated on the surface of cancer cells and immunosuppressive tumor-assoc...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4066406/ https://ncbi.nlm.nih.gov/pubmed/24657487 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ygyno.2014.03.553 |
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