Neurodevelopmental models of transcription factor 4 deficiency converge on a common ion channel as a potential therapeutic target for Pitt Hopkins syndrome

The clinically pleiotropic gene, Transcription Factor 4 (TCF4), is a broadly expressed basic helix-loop-helix (bHLH) transcription factor linked to multiple neurodevelopmental disorders, including schizophrenia, 18q deletion syndrome, and Pitt Hopkins syndrome (PTHS). In vivo suppression of Tcf4 by...

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Detalhes bibliográficos
Publicado no:Rare Dis
Main Authors: Rannals, Matthew D., Page, Stephanie Cerceo, Campbell, Morganne N., Gallo, Ryan A., Mayfield, Brent, Maher, Brady J.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5154382/
https://ncbi.nlm.nih.gov/pubmed/28032012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/21675511.2016.1220468
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