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Targeting telomerase with radiolabeled inhibitors

The expression of telomerase in approximately 85% of cancers and its absence in the majority of normal cells makes it an attractive target for cancer therapy. However the lag period between initiation of telomerase inhibition and growth arrest makes direct inhibition alone an insufficient method of...

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Detalhes bibliográficos
Publicado no:Eur J Med Chem
Main Authors: Waghorn, Philip A., Jackson, Mark R., Gouverneur, Veronique, Vallis, Katherine A.
Formato: Artigo
Idioma:Inglês
Publicado em: Editions Scientifiques Elsevier 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5154340/
https://ncbi.nlm.nih.gov/pubmed/27657809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2016.09.028
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