Radiolabeled Oligonucleotides Targeting the RNA Subunit of Telomerase Inhibit Telomerase and Induce DNA Damage in Telomerase-Positive Cancer Cells

Telomerase is expressed in the majority (>85%) of tumours, but has restricted expression in normal tissues. Long-term telomerase inhibition in malignant cells results in progressive telomere shortening and reduction in cell proliferation. Here we report the synthesis and characterisation of radio...

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Publicado no:Cancer Res
Main Authors: Jackson, Mark R., Bavelaar, Bas M., Waghorn, Philip A., Gill, Martin R., El-Sagheer, Afaf H., Brown, Tom, Tarsounas, Madalena, Vallis, Katherine A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7611324/
https://ncbi.nlm.nih.gov/pubmed/31311806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-18-3594
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