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An Osteopontin/CD44 axis in RhoGDI2-mediated metastasis suppression
RhoGDI2 specifically suppresses bladder cancer metastasis but not primary tumor growth, which involves tumor-associated macrophages. We report that macrophage-secreted osteopontin binds to CD44s on the tumor cells and promotes invasion and clonal growth. These effects are RhoGDI2-sensitive and requi...
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| Gepubliceerd in: | Cancer Cell |
|---|---|
| Hoofdauteurs: | , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2016
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5154333/ https://ncbi.nlm.nih.gov/pubmed/27593345 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2016.08.002 |
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