Targeted Mutagenesis of the Mycobacterium smegmatis mca Gene, Encoding a Mycothiol-Dependent Detoxification Protein

Mycothiol (MSH), a functional analogue of glutathione (GSH) that is found exclusively in actinomycetes, reacts with electrophiles and toxins to form MSH-toxin conjugates. Mycothiol S-conjugate amidase (Mca) then catalyzes the hydrolysis of an amide bond in the S conjugates, producing a mercapturic a...

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Bibliografiske detaljer
Main Authors: Rawat, Mamta, Uppal, Mandeep, Newton, Gerald, Steffek, Micah, Fahey, Robert C., Av-Gay, Yossef
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2004
Fag:
Enzymes and Proteins
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC515152/
https://ncbi.nlm.nih.gov/pubmed/15342574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.186.18.6050-6058.2004
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