Targeted Mutagenesis of the Mycobacterium smegmatis mca Gene, Encoding a Mycothiol-Dependent Detoxification Protein

Mycothiol (MSH), a functional analogue of glutathione (GSH) that is found exclusively in actinomycetes, reacts with electrophiles and toxins to form MSH-toxin conjugates. Mycothiol S-conjugate amidase (Mca) then catalyzes the hydrolysis of an amide bond in the S conjugates, producing a mercapturic a...

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Podrobná bibliografie

Vydáno v:	J Bacteriol
Hlavní autoři:	Rawat, Mamta, Uppal, Mandeep, Newton, Gerald, Steffek, Micah, Fahey, Robert C., Av-Gay, Yossef
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology (ASM) 2004
Témata:	Enzymes and Proteins
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC515152/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15342574/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JB.186.18.6050-6058.2004
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