A small molecule inhibitor of β-catenin/cyclic AMP response element-binding protein transcription

Inherited and somatic mutations in the adenomatous polyposis coli occur in most colon cancers, leading to activation of β-catenin-responsive genes. To identify small molecule antagonists of this pathway, we challenged transformed colorectal cells with a secondary structure-templated chemical library...

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Hlavní autoři: Emami, Katayoon H., Nguyen, Cu, Ma, Hong, Kim, Dae Hoon, Jeong, Kwang Won, Eguchi, Masakatsu, Moon, Randall T., Teo, Jia-Ling, Oh, Se Wong, Kim, Hak Yeop, Moon, Sung Hwan, Ha, Jong Ryul, Kahn, Michael
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2004
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC515116/
https://ncbi.nlm.nih.gov/pubmed/15314234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0404875101
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