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A small molecule inhibitor of β-catenin/cyclic AMP response element-binding protein transcription
Inherited and somatic mutations in the adenomatous polyposis coli occur in most colon cancers, leading to activation of β-catenin-responsive genes. To identify small molecule antagonists of this pathway, we challenged transformed colorectal cells with a secondary structure-templated chemical library...
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| 主要な著者: | , , , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2004
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC515116/ https://ncbi.nlm.nih.gov/pubmed/15314234 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0404875101 |
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