Mechanisms of embryonal tumor initiation: Distinct roles for MycN expression and MYCN amplification
The mechanisms causing persistence of embryonal cells that later give rise to tumors is unknown. One tumorigenic factor in the embryonal childhood tumor neuroblastoma is the MYCN protooncogene. Here we show that normal mice developed neuroblast hyperplasia in paravertebral ganglia at birth that comp...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2004
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC515113/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15314226/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0401083101 |
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