Mechanisms of embryonal tumor initiation: Distinct roles for MycN expression and MYCN amplification

The mechanisms causing persistence of embryonal cells that later give rise to tumors is unknown. One tumorigenic factor in the embryonal childhood tumor neuroblastoma is the MYCN protooncogene. Here we show that normal mice developed neuroblast hyperplasia in paravertebral ganglia at birth that comp...

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Autors principals: Hansford, Loen M., Thomas, Wayne D., Keating, Joanna M., Burkhart, Catherine A., Peaston, Anne E., Norris, Murray D., Haber, Michelle, Armati, Patricia J., Weiss, William A., Marshall, Glenn M.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2004
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC515113/
https://ncbi.nlm.nih.gov/pubmed/15314226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0401083101
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