Mechanisms of embryonal tumor initiation: Distinct roles for MycN expression and MYCN amplification

The mechanisms causing persistence of embryonal cells that later give rise to tumors is unknown. One tumorigenic factor in the embryonal childhood tumor neuroblastoma is the MYCN protooncogene. Here we show that normal mice developed neuroblast hyperplasia in paravertebral ganglia at birth that comp...

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Detalhes bibliográficos
Main Authors: Hansford, Loen M., Thomas, Wayne D., Keating, Joanna M., Burkhart, Catherine A., Peaston, Anne E., Norris, Murray D., Haber, Michelle, Armati, Patricia J., Weiss, William A., Marshall, Glenn M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2004
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC515113/
https://ncbi.nlm.nih.gov/pubmed/15314226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0401083101
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