Discovery of Phenylglycine Lactams as Potent Neutral Factor VIIa Inhibitors

[Image: see text] Inhibitors of Factor VIIa (FVIIa), a serine protease in the clotting cascade, have shown strong antithrombotic efficacy in preclinical thrombosis models with minimal bleeding liabilities. Discovery of potent, orally active FVIIa inhibitors has been largely unsuccessful because know...

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Bibliografske podrobnosti
izdano v:ACS Med Chem Lett
Main Authors: Wurtz, Nicholas R., Parkhurst, Brandon L., Jiang, Wen, DeLucca, Indawati, Zhang, Xiaojun, Ladziata, Vladimir, Cheney, Daniel L., Bozarth, Jeffrey R., Rendina, Alan R., Wei, Anzhi, Luettgen, Joseph M., Wu, Yiming, Wong, Pancras C., Seiffert, Dietmar A., Wexler, Ruth R., Priestley, E. Scott
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2016
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5150698/
https://ncbi.nlm.nih.gov/pubmed/27994741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.6b00282
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