Design and Synthesis of Phenylpyrrolidine Phenylglycinamides As Highly Potent and Selective TF-FVIIa Inhibitors

[Image: see text] Inhibitors of the Tissue Factor/Factor VIIa (TF-FVIIa) complex are promising novel anticoagulants that show excellent efficacy and minimal bleeding in preclinical models. On the basis of a zwitterionic phenylglycine acylsulfonamide 1, a phenylglycine benzylamide 2 was shown to poss...

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Detalhes bibliográficos
Main Authors: Zhang, Xiaojun, Jiang, Wen, Jacutin-Porte, Swanee, Glunz, Peter W., Zou, Yan, Cheng, Xuhong, Nirschl, Alexandra H., Wurtz, Nicholas R., Luettgen, Joseph M., Rendina, Alan R., Luo, Gang, Harper, Timothy M., Wei, Anzhi, Anumula, Rushith, Cheney, Daniel L., Knabb, Robert M., Wong, Pancras C., Wexler, Ruth R., Priestley, E. Scott
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2013
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027585/
https://ncbi.nlm.nih.gov/pubmed/24900796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400453z
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