Design and Synthesis of Phenylpyrrolidine Phenylglycinamides As Highly Potent and Selective TF-FVIIa Inhibitors

[Image: see text] Inhibitors of the Tissue Factor/Factor VIIa (TF-FVIIa) complex are promising novel anticoagulants that show excellent efficacy and minimal bleeding in preclinical models. On the basis of a zwitterionic phenylglycine acylsulfonamide 1, a phenylglycine benzylamide 2 was shown to poss...

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Bibliografische gegevens
Hoofdauteurs: Zhang, Xiaojun, Jiang, Wen, Jacutin-Porte, Swanee, Glunz, Peter W., Zou, Yan, Cheng, Xuhong, Nirschl, Alexandra H., Wurtz, Nicholas R., Luettgen, Joseph M., Rendina, Alan R., Luo, Gang, Harper, Timothy M., Wei, Anzhi, Anumula, Rushith, Cheney, Daniel L., Knabb, Robert M., Wong, Pancras C., Wexler, Ruth R., Priestley, E. Scott
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Chemical Society 2013
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027585/
https://ncbi.nlm.nih.gov/pubmed/24900796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400453z
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