Design and Synthesis of Phenylpyrrolidine Phenylglycinamides As Highly Potent and Selective TF-FVIIa Inhibitors

[Image: see text] Inhibitors of the Tissue Factor/Factor VIIa (TF-FVIIa) complex are promising novel anticoagulants that show excellent efficacy and minimal bleeding in preclinical models. On the basis of a zwitterionic phenylglycine acylsulfonamide 1, a phenylglycine benzylamide 2 was shown to poss...

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主要な著者: Zhang, Xiaojun, Jiang, Wen, Jacutin-Porte, Swanee, Glunz, Peter W., Zou, Yan, Cheng, Xuhong, Nirschl, Alexandra H., Wurtz, Nicholas R., Luettgen, Joseph M., Rendina, Alan R., Luo, Gang, Harper, Timothy M., Wei, Anzhi, Anumula, Rushith, Cheney, Daniel L., Knabb, Robert M., Wong, Pancras C., Wexler, Ruth R., Priestley, E. Scott
フォーマット: Artigo
言語:Inglês
出版事項: American Chemical Society 2013
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027585/
https://ncbi.nlm.nih.gov/pubmed/24900796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400453z
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