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Design and Synthesis of Phenylpyrrolidine Phenylglycinamides As Highly Potent and Selective TF-FVIIa Inhibitors
[Image: see text] Inhibitors of the Tissue Factor/Factor VIIa (TF-FVIIa) complex are promising novel anticoagulants that show excellent efficacy and minimal bleeding in preclinical models. On the basis of a zwitterionic phenylglycine acylsulfonamide 1, a phenylglycine benzylamide 2 was shown to poss...
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| 主要な著者: | , , , , , , , , , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Chemical
Society
2013
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| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4027585/ https://ncbi.nlm.nih.gov/pubmed/24900796 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400453z |
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