Mutant Huntingtin Impairs Axonal Trafficking in Mammalian Neurons In Vivo and In Vitro

Recent data in invertebrates demonstrated that huntingtin (htt) is essential for fast axonal trafficking. Here, we provide direct and functional evidence that htt is involved in fast axonal trafficking in mammals. Moreover, expression of full-length mutant htt (mhtt) impairs vesicular and mitochondr...

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Detalhes bibliográficos
Main Authors: Trushina, Eugenia, Dyer, Roy B., Badger, John D., Ure, Daren, Eide, Lars, Tran, David D., Vrieze, Brent T., Legendre-Guillemin, Valerie, McPherson, Peter S., Mandavilli, Bhaskar S., Van Houten, Bennett, Zeitlin, Scott, McNiven, Mark, Aebersold, Ruedi, Hayden, Michael, Parisi, Joseph E., Seeberg, Erling, Dragatsis, Ioannis, Doyle, Kelly, Bender, Anna, Chacko, Celin, McMurray, Cynthia T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC515048/
https://ncbi.nlm.nih.gov/pubmed/15340079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.18.8195-8209.2004
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