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Substrate recognition and catalysis by GH47 α-mannosidases involved in Asn-linked glycan maturation in the mammalian secretory pathway

Maturation of Asn-linked oligosaccharides in the eukaryotic secretory pathway requires the trimming of nascent glycan chains to remove all glucose and several mannose residues before extension into complex-type structures on the cell surface and secreted glycoproteins. Multiple glycoside hydrolase f...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Xiang, Yong, Karaveg, Khanita, Moremen, Kelley W.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5150396/
https://ncbi.nlm.nih.gov/pubmed/27856750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1611213113
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