Essential and mutually compensatory roles of α-mannosidase II and α-mannosidase IIx in N-glycan processing in vivo in mice

Many proteins synthesized through the secretory pathway receive posttranslational modifications, including N-glycosylation. α-Mannosidase II (MII) is a key enzyme converting precursor high-mannose-type N-glycans to matured complex-type structures. Previous studies showed that MII-null mice synthesiz...

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Autori principali: Akama, Tomoya O., Nakagawa, Hiroaki, Wong, Nyet Kui, Sutton-Smith, Mark, Dell, Anne, Morris, Howard R., Nakayama, Jun, Nishimura, Shin-Ichiro, Pai, Ashok, Moremen, Kelley W., Marth, Jamey D., Fukuda, Michiko N.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2006
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1474017/
https://ncbi.nlm.nih.gov/pubmed/16754854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0603248103
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