Effects of the Δ67 Complex of Mutations in Human Immunodeficiency Virus Type 1 Reverse Transcriptase on Nucleoside Analog Excision

Long-term use of combination therapy against human immunodeficiency virus type (HIV-1) provides strong selective pressure on the virus, and HIV-1 variants that are resistant to multiple inhibitors have been isolated. HIV-1 variants containing amino acid substitutions within the coding region of HIV-...

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Bibliographic Details
Main Authors: Boyer, Paul L., Imamichi, Tomozumi, Sarafianos, Stefan G., Arnold, Edward, Hughes, Stephen H.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2004
Subjects:
Replication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC515022/
https://ncbi.nlm.nih.gov/pubmed/15331732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.18.9987-9997.2004
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