Actin activates Pseudomonas aeruginosa ExoY nucleotidyl cyclase toxin and ExoY-like effector domains from MARTX toxins

The nucleotidyl cyclase toxin ExoY is one of the virulence factors injected by the Pseudomonas aeruginosa type III secretion system into host cells. Inside cells, it is activated by an unknown eukaryotic cofactor to synthesize various cyclic nucleotide monophosphates. ExoY-like adenylate cyclases ar...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Belyy, Alexander, Raoux-Barbot, Dorothée, Saveanu, Cosmin, Namane, Abdelkader, Ogryzko, Vasily, Worpenberg, Lina, David, Violaine, Henriot, Veronique, Fellous, Souad, Merrifield, Christien, Assayag, Elodie, Ladant, Daniel, Renault, Louis, Mechold, Undine
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5150216/
https://ncbi.nlm.nih.gov/pubmed/27917880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13582
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