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Granzymes A and K differentially potentiate LPS-induced cytokine response

Granzymes are serine proteases that, upon release from cytotoxic cells, induce apoptosis in tumor cells and virally infected cells. In addition, a role of granzymes in inflammation is emerging. Recently, we have demonstrated that extracellular granzyme K (GrK) potentiates lipopolysaccharide (LPS)-in...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Cell Death Discov
Hauptverfasser: Wensink, Annette C, Kok, Helena M, Meeldijk, Jan, Fermie, Job, Froelich, Christopher J, Hack, C Erik, Bovenschen, Niels
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5149580/
https://ncbi.nlm.nih.gov/pubmed/28028441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddiscovery.2016.84
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